Current Position
2017. Feb | Professor, Department of Neurosurgery, Spine center, CHA University Scholl of Medicine |
2022. Mar | Vice Dean of Research, CHA University School of Medicine |
Academic Experiences
2014. Feb | Yonsei University, Seoul, South Korea, PhD |
2010-2012 | Research fellowship, Laboratory of Spinal Cord Injury & Stem Cell Biology, Brigham & Women’s Hospital/Harvard Medical School, USA |
Professional Experiences
2022. Sep | Editor-in-Chief |
2024. Mar | Vice Director, Advanced Medical Center, CHA Bundang Medical Center |
2022. Apr | President, The Korean Society of Basic Neurosurgical Sciences |
Presentation Topic
Effective Modulation of Inflammation and Oxidative Stress for Enhanced Regeneration of Intervertebral Discs Using 3D Porous Hybrid Protein Nanoscaffold
Abstract
Degeneration of fibrocartilaginous tissues is often associated with complex pro-inflammatory factors. These include reactive oxygen species (ROS), cell-free nucleic acids (cf-NAs), and epigenetic changes in immune cells. To effectively control this complex inflammatory signaling, it developed an all-in-one nanoscaffold-based 3D porous hybrid protein (3D-PHP) self-therapeutic strategy for treating intervertebral disc (IVD) degeneration. The 3D-PHP nanoscaffold is synthesized by introducing a novel nanomaterial-templated protein assembly (NTPA) strategy. 3D-PHP nanoscaffolds that avoid covalent modification of proteins demonstrate inflammatory stimuli-responsive drug release, disc-mimetic stiffness, and excellent biodegradability. Enzyme-like 2D nanosheets incorporated into nanoscaffolds further enabled robust scavenging of ROS and cf-NAs, reducing inflammation and enhancing the survival of disc cells under inflammatory stress in vitro. Implantation of 3D-PHP nanoscaffolds loaded with bromodomain extraterminal inhibitor (BETi) into a rat nucleotomy disc injury model effectively suppressed inflammation in vivo, thus promoting restoration of the extracellular matrix (ECM). The resulting regeneration of disc tissue facilitated long-term pain reduction. Therefore, self-therapeutic and epigenetic modulator-encapsulated hybrid protein nanoscaffold shows great promise as a novel approach to restore dysregulated inflammatory signaling and treat degenerative fibrocartilaginous diseases, including disc injuries, providing hope and relief to patients worldwide.
Keywords: 2D nanomaterials; 3D hybrid protein nanoscaffolds; epigenetic modification; inflammation; intervertebral disc (IVD) degeneration; nanoscaffolds; oxidative stress; self-assembly.